TALENs and CRISPR

Recombinetics primarily uses two groundbreaking genome editing technologies that allow us to make precise genetic alterations: TALENs (Transcription Activator-Like Effector Nucleases) and CRISPR/Cas9 (Clustered, Regularly Interspaced, Short Palindromic Repeats). Both TALENs and CRISPR use restriction endonucleases that cause a double-strand break (DSBs) at nearly any target.

Recombinetics holds the exclusive license rights for TALENs (Thermo/Cellectis) in food animals for pigs, cattle, sheep; pursuing a license for poultry and aquaculture; and has a non-exclusive license for goats. Our scientists have filed a dozen utility patents supporting the use of these technologies for livestock improvement, including the first enabled livestock animal patent filing using CRISPR/Cas9.gene editing